General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment The overexpression of Sirt1 appears to protect transgenic mice from high-fat diet-induced hepatic inflammation through decreasing the NF-kappaB-mediated induction of inflammatory cytokines, as well as by the activation of antioxidant proteins, possibly mediated by PGC1alpha.
Formal Description
Interaction-ID: 5399



decreases_activity of

if SIRT1 is overexpressed, via decreased NF-kappaB activity