General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment TNF-alpha stimulation resulted in significantly lower activation of NF-kappaB activation in Sirt1-transgenic cells (2.8-fold) compared with wild-type cells (5-fold).
Formal Description
Interaction-ID: 5394



affects_activity of


NF-kappaB complex

if SIRT1 is overexpressed