General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment After 19 weeks of high-fat diet, wild-type mice presented with severe hepatosteatosis, including massive accumulation of large lipid droplets. Importantly, Sirt1 transgenic mice were almost entirely protected from NAFLD, showing a low number of lipid droplets with small diameters.
Formal Description
Interaction-ID: 5381



affects_activity of


Fatty liver disease, nonalcoholic

after 19 weeks of high-fat diet, if SIRT1 is overexpressed