General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment Although Sirt1 transgenic mice present a modest increase in food intake under high-fat diet, this is compensated by a similarly modest increase in energy expenditure, thus indicating a balanced energy homeostasis.
Formal Description
Interaction-ID: 5379



NOT affects_activity of

on high-fat diet, if SIRT1 is overexpressed