General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment Indirect calorimetry revealed that transgenic Sirt1 mice showed higher energy expenditure than wild-type mice on high-fat diet. No differences were observed in mice fed standard diet.
Formal Description
Interaction-ID: 5376



affects_activity of

on high-fat diet, if SIRT1 is overexpressed