General Information:

Id: 904 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
BAC-based transgenic Sirt1 mouse with moderate overexpression of Sirt1
Reference: Pfluger PT et al.(2008) Sirt1 protects against high-fat diet-induced metabolic damage Proc. Natl. Acad. Sci. U.S.A. 105: 9793-9798 [PMID: 18599449]

Interaction Information:

Comment Body weights and body lengths of 8- to 10-week-old transgenic Sirt1 mice did not differ from wild-type (WT) control mice on a standard diet (SD). Subsequent exposure for 19 weeks to a high-fat diet (HFD) did not lead to significant differences in body weight, fat mass, or lean mass, although a trend toward lower body weight and fat mass was observed in transgenic mice on HFD compared with WT controls.
Formal Description
Interaction-ID: 5370



NOT affects_activity of

if SIRT1 is overexpressed