General Information:

Id: 868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
SirBACO: SirT1 bacterial artificial chromosome overexpressor
Reference: Banks AS et al.(2008) SirT1 gain of function increases energy efficiency and prevents diabetes in mice. Cell Metab. 8: 333-341 [PMID: 18840364]

Interaction Information:

Comment In contrast to the findings in SirBACO mice on a normal diet, there were no differences in metabolic rate, spontaneous locomotor activity, or food intake in SirBACO mice on a high-fat diet or crossed onto db/db compared to littermate controls, thus it seems that SirT1 promotes a state of increased energy efficiency that protects against insulin resistance and hyperglycemia.
Formal Description
Interaction-ID: 5186



NOT affects_activity of

on high-fat diet, if SIRT1 is overexpressed