General Information:

Id: 824 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Obesity - [OMIM]
Reference: Sugden MC et al.(2010) PPAR control: its SIRTainly as easy as PGC J Endocrinol 204: 93-104 [PMID: 19770177]

Interaction Information:

Comment The observation that, in liver, TRIB3 is a target for PPAR-alpha and that knockdown of hepatic TRIB3 expression improves glucose tolerance, whereas hepatic overexpression of TRIB3 reverses the insulin-sensitive phenotype of PGC-1-deficient mice has led to the suggestion that TRIB3 inhibitors may have a potential role in the treatment of T2DM. However, chronic reduction of hepatic PGC-1alpha expression has been shown to impair hepatic insulin sensitivity.
Formal Description
Interaction-ID: 13113



affects_activity of

in liver