General Information:

Id: 78 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Mus musculus
BTO:0000991 pancreatic islet
Reference: Lgssiar A et al.(2004) Interleukin-11 inhibits NF-kappaB and AP-1 activation in islets and prevents diabetes induced with streptozotocin in mice Exp. Biol. Med. (Maywood) 229: 425-436 [PMID: 15096655]

Interaction Information:

Comment Interleukin-11 shifts the streptozotocin (MLD-STZ) induced inflammatory responses to anti-inflammatory reactions. STZ increased expression of the proinflammatory cytokine TFN-alpha.
Formal Description
Interaction-ID: 256

drug/chemical compound


increases_expression of



in male mice
Drugbank entries Show/Hide entries for Streptozocin or TNF