fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599
Ceramides C18:0, C24:1 and sulfatide were increased in the MFG (middle frontal gyrus) grey matter of ApoE4 AD patients (1.8- to 2.0-fold).
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