General Information:

Id: 7,848 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
fresh frozen brain tissue blocks of middle frontal gyrus (MFG), middle temporal gyrus (MTG), and cerebellum were obtained from normal subjects and cases of definite AD diagnosed according to CERAD criteria
Reference: Bandaru VV et al.(2009) ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimers but not normal brain Neurobiol. Aging 30: 591-599 [PMID: 17888544]

Interaction Information:

Comment In the MTG (middle temporal gyrus) grey matter, only the cholesterol ester C18:1 was elevated (2.4-fold) in AD patients expressing ApoE4 compared with AD patients expressing ApoE3.
Formal Description
Interaction-ID: 78369

gene/protein mutant

APOE (isoform E4)

increases_quantity of

drug/chemical compound

Cholesterol ester C18:1

in the MTG (middle temporal gyrus) grey matter in AD patients expressing ApoE4, (in the cell bodies but not in the fiber tracks); (2.4-fold increase), compared with AD patients expressing ApoE3