General Information:

Id: 76 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type I - [OMIM]
Rattus norvegicus
BTO:0000991 pancreatic islet
Reference: Kim EK et al.(2007) Activation of peroxisome proliferator-activated receptor-gamma protects pancreatic beta-cells from cytokine-induced cytotoxicity via NF kappaB pathway. Int. J. Biochem. Cell Biol. 39: 1260-1275 [PMID: 17521952]

Interaction Information:

Comment Pretreatment with CGZ or TGZ blocked the IL-1-beta and IFN-gamma effect and restored islet cell insulin secretion to near control levels.
Formal Description
Interaction-ID: 242

drug/chemical compound


increases_activity of

in pancreatic islets; in cytokine treated cells