General Information:

Id: 7,430 (click here to show other Interactions for entry)
Diseases: Coronary heart disease
Homo sapiens
Reference: Shahid SU et al.(2016) Effect of SORT1, APOB and APOE polymorphisms on LDL-C and coronary heart disease in Pakistani subjects and their comparison with Northwick Park Heart Study II Lipids Health Dis 15: 83 [PMID: 27112212]

Interaction Information:

Comment SNPs on LDL-C and coronary heart disease (CHD) was examined in Pakistani subjects and was compared with middle aged UK men from Northwick Park Heart Study II (NPHSII). One thousand nine hundred sixty-five (1770 non CHD, 195 CHD) UK and 623 (219 non CHD, 404 CHD) Pakistani subjects were enrolled in the study. The SNPs SORT1 rs646776, APOB rs1042031 and APOE rs429358, rs7412 were genotyped. The SNPs show a dose response association with LDL-C levels and risk of CHD in both populations. For the APOE polymorphisms, rs429358 and rs7412, isoforms epsilon2, epsilon3 and epsilon4 were examined separately. When compared with epsilon3, epsilon2 lowered LDL-C while epsilon4 raised LDL-C in all the study groups.
Formal Description
Interaction-ID: 73241

gene/protein mutant

APOE (isoform E4)

increases_activity of

compared to APOE (isoform E3)