General Information:

Id: 7,322 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Mielke MM et al.(2014) Clinical epidemiology of Alzheimers disease: assessing sex and gender differences Clin Epidemiol 6: 37-48 [PMID: 24470773]

Interaction Information:

Comment The E4 allele of the apolipoprotein E (APOE) gene is the strongest known genetic risk factor for late-onset AD. Compared to non-carriers, heterozygous carriers of one E4 allele are 3–4 times more likely to develop AD, whereas the risk for homozygous carriers is even higher. The APOE E4 allele is specifically associated with an earlier age of onset of AD.
Formal Description
Interaction-ID: 71967

gene/protein mutant

APOE (isoform E4)

increases_activity of