General Information:

Id: 7,322 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: Mielke MM et al.(2014) Clinical epidemiology of Alzheimers disease: assessing sex and gender differences Clin Epidemiol 6: 37-48 [PMID: 24470773]

Interaction Information:

Comment The effects of the E4 genotype are more pronounced in women than in men. Three studies reported that women with one E4 allele had about a four-fold risk of AD, whereas men with one E4 allele showed little increased risk.
Formal Description
Interaction-ID: 124712


sex, male

decreases_activity of

gene/protein mutant

APOE (isoform E4)

in males / men; concerning AD, compared to females / women