General Information:

Id: 7,308 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
Reference: Couttas TA et al.(2014) Loss of the neuroprotective factor Sphingosine 1-phosphate early in Alzheimers disease pathogenesis Acta Neuropathol Commun 2: 9 [PMID: 24456642]

Interaction Information:

Comment Over 99% of AD cases are the age-related, late onset form of the disease, for which the greatest genetic risk factor is the APOE4 allele. Apolipoprotein E (ApoE) is a major lipid transport protein of the central nervous system (CNS) that also mediates the transport and clearance of Abeta. Homozygous carriers of the APOE4 allele have a 12-fold increased risk of developing AD, compared with non-carriers. (cited information)
Formal Description
Interaction-ID: 71708

gene/protein mutant

APOE (isoform E4)

increases_activity of

Comment S1P/sphingosine ratio was 2.5-fold higher in hippocampus of ApoE2 carriers compared to ApoE4 carriers, and multivariate regression showed a significant association between APOE genotype and hippocampal S1P/sphingosine (pā€‰=ā€‰0.0495), suggesting a new link between APOE genotype and pre-disposition to AD.
Formal Description
Interaction-ID: 71716

gene/protein mutant

APOE (isoform E4)

decreases_activity of


S1P/sphingosine ratio

in hippocampus