General Information:

Id: 7,288 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
Reference: Dupuy AM et al.(2001) The relationship between apolipoprotein E4 and lipid metabolism is impaired in Alzheimers disease Gerontology 47: 213-218 [PMID: 11408727]

Interaction Information:

Comment A significant association was observed between the E4 allele and AD only below age 80. In the control group, cholesterol levels were found to be significantly higher in men but not in women with an E4 allele (6.35 +/- 1.3 mmol/l) as opposed to those without (5.8 +/- 1.2 mmol/l).
Formal Description
Interaction-ID: 73921

gene/protein mutant

APOE (isoform E4)

increases_activity of

only below age 80