General Information:

Id: 7,250 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
HEK293 cells; ES-cell-derived human neurons
Reference: Huang YA et al.(2017) ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion Cell 168: 427-441.e21 [PMID: 28111074]

Interaction Information:

Comment All three ApoE isoforms robustly enhanced Abeta-synthesis, but with strikingly different efficacy (ApoE4>ApoE3>ApoE2). This differential efficacy was observed for total Abeta, Abeta40, or Abeta42, and for secreted as well as cellular Abeta, and was unrelated to alpha-or beta-secretase expression.
Formal Description
Interaction-ID: 124917

gene/protein mutant

APOE (isoform E4)

increases_quantity of

compared to ApoE3 and ApoeE2; unrelated to alpha-or beta-secretase expression