General Information:

Id: 7,238 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
Reference: [PMID: 28035934]

Interaction Information:

Comment Among men, the highest tertile of most ceramides and sphingomyelins were associated with an increased risk of AD. Among women, there were no associations between any of the ceramides and risk of AD. In contrast, women in the highest tertile of most sphingomyelins had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship.
Formal Description
Interaction-ID: 71259



affects_activity of

gene/protein mutant

APOE (isoform E4)

in plasma; concerning the risk of AD in the Baltimore Longitudinal Study of Aging;