General Information:

Id: 7,238 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
Reference: [PMID: 28035934]

Interaction Information:

Comment Women in the highest tertile of most sphingomyelins (except SM C20 : 1) had a reduced risk of AD, which was most pronounced among APOE (isoform E4) carriers. These results provide further evidence for the role of sphingolipid metabolism in AD and highlight the importance of considering sex and APOE genotype in assessing this relationship.
Formal Description
Interaction-ID: 71247

gene/protein mutant

APOE (isoform E4)

decreases_activity of

in plasma; among women, in the Baltimore Longitudinal Study of Aging;