General Information:

Id: 714 (click here to show other Interactions for entry)
Diseases: Abetalipoproteinemia - [OMIM]
Cardiovascular disease
Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mammalia
review
Reference: Kamagate A and Dong HH(2008) FoxO1 integrates insulin signaling to VLDL production. Cell Cycle 7: 3162-3170 [PMID: 18927507]

Interaction Information:

Comment FoxO1 mediates the inhibitory effect of insulin on the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), two key enzymes in hepatic gluconeogenesis.
Formal Description
Interaction-ID: 4046

gene/protein

PCK1

increases_activity of

process

gluconeogenesis

Drugbank entries Show/Hide entries for PCK1