General Information:

Id: 710 (click here to show other Interactions for entry)
Diseases: Parkinson disease
BTO:0003945 MN9D cell; BTO:0000298 COS-7 cell
Reference: Rawal N et al.(2009) Parkin protects dopaminergic neurons from excessive Wnt/beta-catenin signaling Biochem. Biophys. Res. Commun. 388: 473-478 [PMID: 19591802]

Interaction Information:

Comment Parkin regulates canonical Wnt/beta-catenin signaling by reducing the pool of active beta-catenin upon Wnt3a stimulation.
Formal Description
Interaction-ID: 3950



affects_activity of

Comment Wnt3a is a canonical Wnt that binds to Frizzled receptors, preventing phosphorylation of beta-catenin, thereby stabilizing it, allowing it to enter the nucleus and initiate transcription of target genes.
Formal Description
Interaction-ID: 3953



affects_activity of

Comment Wnt/beta-catenin signaling is important during the development of ventral midbrain DA neurons.
Formal Description
Interaction-ID: 3955
Comment Excessive Wnt/beta-catenin signaling in differentiated ventral midbrain neurons results in cell cycle re-entry followed by DA cell death.
Formal Description
Interaction-ID: 3966

increases_activity of

in differentiated ventral midbrain neurons