General Information:

Id: 6,523 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, diabetic
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Zou MH and Wu Y(2008) AMP-activated protein kinase activation as a strategy for protecting vascular endothelial function Clin. Exp. Pharmacol. Physiol. 35: 535-545 [PMID: 18177481]

Interaction Information:

Comment The endothelium is a single layer of cells that covers the inner surface of all vessels in the body, including conduit vessels, resistance vessels, precapillary arterioles and capillaries. The endothelial layer forms a barrier between the elements of the blood and the tissues by virtue of its direct contact with the circulating blood. The intact function and structure of the endothelium are prerequisite for maintaining normal vascular function and anti-atherogenesis. The arterial wall endothelium has various important physiological functions, including adjusting vascular tone and permeability, antithrombosis and the secretion of diverse active materials. Arterial wall endothelium damage is an initiating factor for atherogenesis. The endothelium is susceptible to changes in blood elements, such as increases in blood glucose or free fatty acids (FFAs), angiotensin II, adrenaline, noradrenaline, bradykinin, as well as hypertension and hypercholesterolaemia. All these factors can cause vascular endothelium damage.
Formal Description
Interaction-ID: 62375


Angiotensin II

increases_activity of