General Information:

Id: 651 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Mus musculus
PDAPP (APPV717F) mouse
Reference: Ryder J et al.(2003) Divergent roles of GSK3 and CDK5 in APP processing. Biochem. Biophys. Res. Commun. 312: 922-929 [PMID: 14651959]

Interaction Information:

Comment Roscovitine, a CDK5 inhibitor, augmented Ab (amyloid beta peptide) production in the brains of PDAPP (APPV717F) mice. These data provide first evidence that CDK5 inhibition modulates Ab production.
Formal Description
Interaction-ID: 3452

drug/chemical compound


increases_quantity of


Amyloid beta peptide

in brain