General Information:

Id: 6,519 (click here to show other Interactions for entry)
Diseases: Cardiomyopathy, diabetic
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Bos taurus
Reference: Ouslimani N et al.(2005) Metformin decreases intracellular production of reactive oxygen species in aortic endothelial cells Metab. Clin. Exp. 54: 829-834 [PMID: 15931622]

Interaction Information:

Comment Intracellular ROS (reactive oxygen species) production was measured by fluorescence of the DCF (2,7-dichlorodihydrofluorescein) probe. The results showed that metformin was able to reduce the intracellular production of ROS in both nonstimulated BAECs (-20%) and BAEC stimulated by high levels of glucose or angiotensin II (-28% and -72%, respectively).
Formal Description
Interaction-ID: 61998


Angiotensin II

increases_quantity of

drug/chemical compound

Reactive oxygen species

in aortic endothelial cells