General Information:

Id: 6,387 (click here to show other Interactions for entry)
Diseases: Metabolic
Reference: Cetrullo S et al.(2015) mTOR, AMPK, and Sirt1: Key Players in Metabolic Stress Management Crit. Rev. Eukaryot. Gene Expr. 25: 59-75 [PMID: 25955819]

Interaction Information:

Comment Two studies have reported an interaction between Sirt1 and CLOCK-BMAL1, joint master regulators of the circadian clock, which implies that Sirt1 is the molecular link among several cellular processes, playing a regulatory role in the circadian clock, aging, cellular metabolism, and stress response. These different processes are characterized by changes in NAD+ levels and in turn influence Sirt1 activity in a fine and detailed circuit.
Formal Description
Interaction-ID: 61630



affects_activity of


circadian clock