General Information:

Id: 614 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Homo sapiens
Reference: Kang DE et al.(2002) Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis Cell 110: 751-762 [PMID: 12297048]

Interaction Information:

Comment Wnt signaling rapidly decreased the steady-state levels of P-33/37/41 (=phosphorylated at positions 33, 37, and 41) but not P-45 (=S45-phosphorylated) beta-catenin resulting in accumulation of cytosolic beta-catenin.
Formal Description
Interaction-ID: 3294

decreases_quantity of

protein modification


(= sequentially phosphorylated CTNNB1 at sites 33,37,41)