General Information:

Id: 591 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0004488 NSC-34 cell
Reference: Ferri A et al.(2006) Familial ALS-superoxide dismutases associate with mitochondria and shift their redox potentials Proc. Natl. Acad. Sci. U.S.A. 103 [PMID: 16945901]

Interaction Information:

Comment MutSOD1s themselves may contribute to creating a prooxidant environment, because expression of many of the mutSOD1s was found to shift the GSH/GSSG ratio toward the oxidized form in mitochondria of motoneuronal cells, irrespective of the basal level.
Formal Description
Interaction-ID: 13783

gene/protein mutant


increases_activity of

in mitochondria