General Information:

Id: 5,868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Teperino R et al.(2014) Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin. Cell Dev. Biol. 33: 81-92 [PMID: 24862854]

Interaction Information:

Comment Hedgehog acts upstream of PPARgamma to channel preadipocytes fate away from adipogenesis towards osteogenesis. This is achieved via Gli-dependent induction of anti-adipogenic transcription factors, with concomitant inhibition of the pro-adipogenic ones. Interestingly, Hedgehog-dependent adipogenesis block is restricted to white adipocyte progenitors. aP2-Sufu knockout mice (which feature constitutive activation of the pathway in both white and brown fat depots) display a white adipose tissue-specific lipoatrophy, with a fully developed and functionally intact brown adipose tissue depot. Thus, Hedgehog was one of the first hormonal axes identified capable of differentially regulating white and brown adipogenesis.
Formal Description
Interaction-ID: 55498

decreases_activity of

in white adipose tissue