General Information:

Id: 5,868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Teperino R et al.(2014) Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin. Cell Dev. Biol. 33: 81-92 [PMID: 24862854]

Interaction Information:

Comment The hepatocellular carcinoma (HCC) scenario is rather unique. Here, Hedgehog ligands are secreted by malignant hepatocytes, induce Gli-dependent Warburg reprogramming and lactate secretion in stromal cells (mainly myofibroblasts) and lactate signals back to malignant hepatocytes to sustain their growth and survival. This metabolic reprogramming is known as the “Reverse Warburg”. First introduced in 2009, a reverse Warburg effect describes the ability of cancer cells to induce a Warburg effect in neighbouring stromal cells and benefit from the secreted lactate to sustain their proliferation and survival.
Formal Description
Interaction-ID: 55490

increases_activity of


reverse Warburg effect

in hepatocellular carcinoma cells