General Information:

Id: 5,868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Teperino R et al.(2014) Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin. Cell Dev. Biol. 33: 81-92 [PMID: 24862854]

Interaction Information:

Comment In response to damage, hepatic stellate cells (HSCs) undergo an Epithelial-to-Mesenchymal-Transition (EMT) and trans-differentiate into myofibroblasts (MF), resulting in liver fibrosis. Activation of the Hedgehog pathway in HSCs, for example downstream of Leptin signalling, is responsible for HSC to MF trans-differentiation. This cell fate transition is intriguingly dependent upon Gli transcription factors, Hif-1alpha and a metabolic switch towards aerobic glycolysis in HSCs. These findings represent the first evidence of a direct implication of canonical Gli-dependent Hedgehog signalling in glycolytic reprogramming of cellular metabolism. Strikingly, this phenomenon seems to be a common feature of liver damage-induced Hedgehog signalling, as it has been shown in other forms of non-carcinogenic liver damage.
Formal Description
Interaction-ID: 55489

increases_activity of


aerobic glycolysis

in hepatic stellate cells; upon liver damage