General Information:

Id: 5,868 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Teperino R et al.(2014) Canonical and non-canonical Hedgehog signalling and the control of metabolism Semin. Cell Dev. Biol. 33: 81-92 [PMID: 24862854]

Interaction Information:

Comment Loss of Hedgehog function in the fly results in a disorganized lawn of spiky processes and denticles on the surface of the fly larva, a Hedgehog-like phenotype that coined the name of the pathway. The primary cilium, commonly thought to be a prerogative of Hedgehog signalling in vertebrates, has also been shown to play a central role in flies. Vertebrate canonical Hedgehog signalling is initiated by binding of proteolytically processed and lipid modified Hedgehog ligand to its receptor Patched (Ptch), a twelve-pass transmembrane protein that represses the pathway in the absence of ligand. Three distinct co-receptors, Cdo, Boc, and Gas1, facilitate high-affinity binding of mature Hedgehog ligand to Ptch, thereby enhancing Hedgehog signal strength.
Formal Description
Interaction-ID: 55450



increases_activity of

in primary cilium; via increased binding of SHH to PTCH1