General Information:

Id: 5,861 (click here to show other Interactions for entry)
Diseases: Bardet-Biedl syndrome 19 - [OMIM]
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Ift27(null1) mouse
Reference: Eguether T et al.(2014) IFT27 links the BBSome to IFT for maintenance of the ciliary signaling compartment Dev. Cell 31: 279-290 [PMID: 25446516]

Interaction Information:

Comment Vertebrate hedgehog signaling is coordinated by the differential localization of the receptors patched-1 and Smoothened in the primary cilium. Cilia assembly is mediated by intraflagellar transport (IFT), and cilia defects disrupt hedgehog signaling, causing many structural birth defects. Ift25 and Ift27 knockout mice show structural birth defects indicative of hedgehog signaling dysfunction.
Formal Description
Interaction-ID: 55401



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