General Information:

Id: 5,860 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Zhang Q et al.(2012) BBS proteins interact genetically with the IFT pathway to influence SHH-related phenotypes Hum. Mol. Genet. 21: 1945-1953 [PMID: 22228099]

Interaction Information:

Comment To determine whether the increased ciliary localization of Smo activates the Shh pathway, the expression of Gli1 and Ptch1 was analyzed, two genes whose expressions are upregulated when the Shh pathway is activated. The increased ciliary localization of Smo in the absence of normal BBS genes results in a 20– 30% decrease in Shh pathway activation in MEF cells. These results are consistent with the notion that ciliary localized Smo has two states: inactive and active. Ciliary localization of Smo is not sufficient to activate the pathway. The BBSome may modulate the conversion of Smo from the inactive to the active state within cilia.
Formal Description
Interaction-ID: 55398



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