General Information:

Id: 5,841 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Landsman L et al.(2011) Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice Proc. Natl. Acad. Sci. U.S.A. 108 [PMID: 21969560]

Interaction Information:

Comment Increased Hedgehog (Hh) signaling in adult beta-cells, induced by simultaneous expression of an activated form of the GLI2 transcription factor and the elimination of primary cilia in compound transgenic animals, results in glucose intolerance.
Formal Description
Interaction-ID: 55181

increases_activity of

in adult pancreatic beta cells