General Information:

Id: 5,425 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Retinopathy, diabetic
Homo sapiens
BTO:0002335 ARPE-19 cell
Reference: Liu Q et al.(2013) Nitrosative stress plays an important role in Wnt pathway activation in diabetic retinopathy Antioxid. Redox Signal. 18: 1141-1153 [PMID: 23066786]

Interaction Information:

Comment Elevated levels of phosphorylated LRP6 and nonphosphorylated beta-catenin were observed at 20 min of peroxynitrite (PN) treatment, demonstrating activation of the Wnt pathway. The Wnt signaling induced by PN was significantly attenuated by uric acid (UA), a natural scavenger of PN. These results suggested that nitrosative stress contributes to activation of the Wnt-signaling pathway.
Formal Description
Interaction-ID: 52980

drug/chemical compound


decreases_activity of

if Wnt signaling is induced by peroxynitrite