General Information:

Id: 5,410 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Garcia-Jimenez C et al.(2013) A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 52: R51-R66 [PMID: 24049067]

Interaction Information:

Comment WNT stimulation alone is not enough to promote nuclear accumulation of beta-catenin, but this process requires and depends on high glucose to increase its nuclear retention in a variety of human tumor-derived cell lines related to cancers associated with hyperglycemia and diabetes. As nuclear accumulation of beta-catenin is a well-known tumor marker of bad prognosis, constitutive WNT signaling in cancer on one side, and increased glucose uptake by tumor cells on the other, reveals a previously unrecognized requisite for WNT signaling in cancer, namely its amplification by high glucose. The ability of high glucose to amplify WNT/beta-catenin signaling provides a link between cancer and hyperglycemia which is independent of inflammation, hyperinsulinemia, or ROS induced mutations.
Formal Description
Interaction-ID: 52822

increases_transport of



into the nucleus; amplified by hyperglycemia
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