General Information:

Id: 5,410 (click here to show other Interactions for entry)
Diseases: Cancer
Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Garcia-Jimenez C et al.(2013) A new link between diabetes and cancer: enhanced WNT/beta-catenin signaling by high glucose J Mol Endocrinol 52: R51-R66 [PMID: 24049067]

Interaction Information:

Comment Direct links between WNT signaling and diabetes are illustrated by the mutations reported in its effector, the transcription factor TCF7L2 (previously known as TCF4), which represent the strongest genetic link with diabetes in all ethnicities. The role of the TCF7L2 intronic mutations associated with diabetes has remained elusive, but since their discovery, WNT/beta-catenin signaling has been shown to increase the expression of incretin hormones that are global regulators of metabolism and are required for normal glucose-dependent insulin secretion. As such, WNT-mediated induction of incretin production established a new link between WNT and diabetes.
Formal Description
Interaction-ID: 52810



affects_activity of