General Information:

Id: 533 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Amyotrophic lateral sclerosis
Homo sapiens
BTO:0000007 HEK-293 cell
Reference: Rudrabhatla P et al.(2008) Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein J. Biol. Chem. 283 [PMID: 18635547]

Interaction Information:

Comment Experimental motor neuron disease models are characterized by oxidative stress leading to the accumulation of phospho-NFs within perikarya. Treatment of transfected HEK293 cells with H(2)O(2) resulted in 6-fold increase of phosphorylated NF-H.
Formal Description
Interaction-ID: 2671

increases_quantity of

protein modification