General Information:

Id: 5,327 (click here to show other Interactions for entry)
Diseases: Metabolic
Sleep disorders
Mus musculus
Reference: Chaves I et al.(2014) Insulin-FOXO3 signaling modulates circadian rhythms via regulation of clock transcription Curr. Biol. 24: 1248-1255 [PMID: 24856209]

Interaction Information:

Comment Knockdown of FoxO3 dampens circadian amplitude, an effect that is rescued by overexpression of Clock. binding of FOXO3 to two Daf-binding elements (DBEs) located in the Clock promoter area, implicating Clock as a transcriptional target of FOXO3. Transcriptional oscillation of both core clock and output genes in the liver of FOXO3-deficient mice is affected, indicating a disrupted hepatic circadian rhythmicity.
Formal Description
Interaction-ID: 52079



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