General Information:

Id: 5,311 (click here to show other Interactions for entry)
Diseases: Sleep disorders
Rattus norvegicus
Reference: Tachikawa M et al.(2012) A clearance system for prostaglandin D2, a sleep-promoting factor, in cerebrospinal fluid: role of the blood-cerebrospinal barrier transporters J. Pharmacol. Exp. Ther. 343: 608-616 [PMID: 22931759]

Interaction Information:

Comment Prostaglandin PG D2 is an endogenous sleep-promoting substance that regulates physiological sleep, both non-rapid eye movement and rapid eye movement sleep, through D-type prostanoid receptor 1 (DP1 receptor). Because the DP1 receptors are localized predominantly in the arachnoid trabecular cells in the ventral surface of the rostal basal forebrain, which faces the CSF, the CSF concentration of PG D2 will be a key determinant of the action of DP1 receptors. In unanesthetized conscious rats, the CSF concentration of PG D2 exhibits a significant circadian fluctuation with a peak (1197 pg/ml; 3.4 nM) at 2:00 PM and a minimum (438 pg/ml; 1.2 nM) at 6:00 AM. regulatory systems for the generation and/or elimination of PG D2 in the CSF produce a circadian rhythm. (cited information)
Formal Description
Interaction-ID: 51849


prostaglandin D2 transport from CSF

affects_activity of