General Information:

Id: 5,241 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Reference: Dominy JE Jr et al.(2010) Nutrient-dependent regulation of PGC-1alphas acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5 Biochim. Biophys. Acta 1804: 1676-1683 [PMID: 20005308]

Interaction Information:

Comment Levels of Sirt1 have been reported to change in response to nutrients. Some investigators have found that Sirt1 transcription is inversely responsive to changes in nutrient load by a mechanism that is dependent upon either the transcription factor Foxo3a or the transcriptional co-repressor CtBp and its binding partner Hypermethylated In Cancer. Others, however, report that there are increases in Sirt1 protein caused by nutrient deprivation in both cultured cells and mice, but are not accompanied by changes in the rates of transcription or in steady-state mRNA levels. Among these reports there is disagreement as to whether Sirt1 actually increases in the liver. From this body of work, it is clear that additional studies need to be done to establish the exact mechanism by which Sirt1 protein is controlled by nutriture and if this control is cell autonomous or tissue specific.
Formal Description
Interaction-ID: 51121



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