General Information:

Id: 462 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Fatty liver disease, nonalcoholic
Insulin resistance
Mus musculus
male
short-term overexpression of AMPK specifically in the liver by adenovirus-mediated transfer of a gene encoding a constitutively active form of AMPKalpha2 (AMPKalpha2-CA)
article
Reference: Foretz M et al.(2005) Short-term overexpression of a constitutively active form of AMP-activated protein kinase in the liver leads to mild hypoglycemia and fatty liver. Diabetes 54: 1331-1339 [PMID: 15855317]

Interaction Information:

Comment The effect of a short-term overexpression of AMPK specifically in the liver by adenovirus-mediated transfer of a gene encoding a constitutively active form of AMPKalpha2 (AMPKalpha2-CA) was investigated. Hepatic AMPKalpha2-CA expression significantly decreased blood glucose levels and gluconeogenic gene expression (PEPCK and G6Pase).
Formal Description
Interaction-ID: 2089

complex/PPI

AMPK

affects_activity of

process

gluconeogenesis