General Information:

Id: 457 (click here to show other Interactions for entry)
Diseases: Alzheimer disease - [OMIM]
Reference: de la Monte SM(2009) Insulin resistance and Alzheimers disease BMB Rep 42: 475-481 [PMID: 19712582]

Interaction Information:

Comment Inhibition of insulin/IGF-1 signaling blocks the Wnt pathway, which negatively regulates GSK-3beta via a PI3K/Akt-independent mechanism. In AD, both PI3K/Akt and Wnt signaling have been linked to key molecular abnormalities in AD.
Formal Description
Interaction-ID: 2073

affects_activity of