General Information:

Id: 4,462 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Liu C et al.(2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism Nature 7143: 477-481 [PMID: 17476214]

Interaction Information:

Comment PEPCK (PCK1), a rate-limiting enzyme of hepatic gluconeogenesis, shows a daily cycle that peaks at CT13 in the wild-type liver. PGC-1alpha seems to be dispensable for the rhythmic expression of this enzyme. Nevertheless, the mRNA levels of PEPCK are constitutively elevated at CT1 and CT13, in a similar way to the previous studies. Pyruvate dehydrogenase kinase 4 (PDK4) is a key regulator of the pyruvate dehydrogenase complex that controls the flux of pyruvate into the tricarboxylic acid cycle. The diurnal PDK4 expression is severely impaired in PGC-1alpha-deficient liver and skeletal muscle, although the phase of PDK4 oscillation seems to be preserved. Similarly, the cyclic expression of fatty acid binding protein 3 (Fabp3/H-FABP) as well as other mitochondrial genes involved in oxidative phosphorylation (OXPHOS), such as aconitase (Aco2) and Cox4a (Cox4i1), is also disrupted in PGC-1alpha null skeletal muscle. Together, the results illustrate that PGC-1alpha is essential for oscillatory expression of clock and metabolic genes in vivo.
Formal Description
Interaction-ID: 45370

affects_activity of


Pyruvate dehydrogenase complex

via PPARGC1A and PDK4