General Information:

Id: 4,462 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Mus musculus
Reference: Liu C et al.(2007) Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism Nature 7143: 477-481 [PMID: 17476214]

Interaction Information:

Comment Analysis of PGC-1alpha mRNA levels in mouse liver revealed a diurnal rhythm that peaks at CT13 (CT0 is the onset at hour 0 of subjective light period), gradually declines thereafter, and reaches a nadir at CT1. PGC-1alpha expression is similarly rhythmic in skeletal muscle, though to a lesser degree. The expression of other PGC-1 coactivators, that is, PGC-1beta and PRC, also show circadian rhythms in these tissues.
Formal Description
Interaction-ID: 45352

affects_expression of



in liver, in skeletal muscle