General Information:

Id: 4,370 (click here to show other Interactions for entry)
Diseases: Diabetes mellitus, type II - [OMIM]
Insulin resistance
Rattus norvegicus
primary neuron culture
Reference: Tajes M et al.(2009) Anti-aging properties of melatonin in an in vitro murine senescence model: involvement of the sirtuin 1 pathway J. Pineal Res. 47: 228-237 [PMID: 19650880]

Interaction Information:

Comment Sirtuins are a family of nicotinamide adenine dinucleotide (NAD)-dependent deacetylases (class III histone deacetylases). In this study, an in vitro model of neuronal aging was used to test in several ways whether melatonin acts as a sirtuin 1 inducer and if this effect could be neuroprotective. It is shown that melatonin is able to increase the level of this deacetylase in young primary neurons, as well as in aged neurons.
Formal Description
Interaction-ID: 44566

drug/chemical compound


increases_expression of



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