General Information:

Id: 4,016 (click here to show other Interactions for entry)
Diseases: Circadian rhythm
Colorectal cancer - [OMIM]
Homo sapiens
BTO:0000195 CACO-2 cell
Reference: Ballesta A et al.(2011) A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery PLoS Comput. Biol. 7 [PMID: 21931543]

Interaction Information:

Comment After cell synchronization with a serum shock defining Circadian Time (CT) 0, circadian rhythms with a period of 26 h 50 (SD 63 min) were observed in the mRNA expression of clock genes REV-ERBalpha, PER2, BMAL1, the drug target topoisomerase 1 (TOP1), the activation enzyme carboxylesterase 2 (CES2), the deactivation enzyme UDP-glucuronosyltransferase 1, polypeptide A1 (UGT1A1), and efflux transporters ABCB1, ABCC1, ABCC2 and ABCG2.
Formal Description
Interaction-ID: 41243

affects_expression of