General Information:

Id: 385 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Homo sapiens
BTO:0003350 BV-2 cell
Reference: Liu Y et al.(2009) Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2 J. Biol. Chem. 284: 3691-3699 [PMID: 19091752]

Interaction Information:

Comment ADAM10 and 17 are involved in SOD1 G93A mutation-enhanced TNF-alpha secretion following TLR2 stimulation. Following ADAM10 or ADAM17 gene silencing, the mSOD1(G93A)-induced enhancement of microglial TNF-alpha release was reversed.
Formal Description
Interaction-ID: 1606



affects_quantity of



in TLR2 stimulated murine microglial cell line BV-2; if SOD1(G93A) is overexpressed
Drugbank entries Show/Hide entries for ADAM17 or TNF