General Information:

Id: 379 (click here to show other Interactions for entry)
Diseases: Amyotrophic lateral sclerosis
Mus musculus
SOD1(G93A) transgenic mouse
BTO:0001279 spinal cord
Reference: Petri S et al.(2007) The lipophilic metal chelators DP-109 and DP-460 are neuroprotective in a transgenic mouse model of amyotrophic lateral sclerosis J. Neurochem. 102: 991-1000 [PMID: 17630988]

Interaction Information:

Comment Treatment of SOD1(G93A) transgenic mice with the lipophilic metal chelators DP-109 and DP-460 (calcium, zinc, and copper chelating compounds) resulted in decreased oxidative stress. DP-109 and DP-460 are diester derivatives of BAPTA [1,2-bis(2-aminophenyloxy)ethane-N,N,N',N'-tetra acetic acid].
Formal Description
Interaction-ID: 1554

drug/chemical compound

Lipophilic metal chelator DP-460

decreases_activity of

in SOD1(G93A) transgenic mice